The Binding Of Isaac: Repentanceis the third and final expansion for theBinding of Isaacseries. It wraps up the story and adds hundreds of new items, trinkets, two new characters, and new paths for the player to take – and there are alotof newBinding of Isaac Repentanceitems.
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While some fans claim the new expansion ismuch more difficultthanAfterbirthorAfterbirth+,there are many new items that either flat out break the game or combine well with just about anything. Edmund McMillen, the creator of the game, even said that the new meta’s difficulty is meant to force fans to try new methods of completing runs.
Updated July 30, 2025 by Erik Petrovich:Part of what makes The Binding of Isaac: Repentance so replayable is the completely unique items that the new DLC gives players. Items like Quints, which create hordes of followers, can be easily broken in The Binding of Isaac’s alternate Greed Mode while being not so useful in a normal run. When it comes toRepentance new items, there are still combos that fans are figuring out months after the DLC was released. Thebest Repentance itemsfundamentally change how a player gets through a run, like opening new explorable areas or granting an extremely powerful new ability.
12Quints
The Quints item looks like a group of five grey followers mirroring each other, and its granted passive ability is absolutely broken. Whenever the player kills an enemy, a random familiar will spawn at their death location and fire their respective tears in the same direction as Isaac.
The newly spawned familiars can’t move, and they will despawn upon leaving the room. However, using Lilith in Greed Mode gives the potential for twice as many spawned familiars as usual, which piles up exponentially as long as the player doesn’t leave the room. Even Greedier mode becomes a walk in the park with this method.
11Tooth and Nail
Tooth and Nail is a deceptively simple item that can make exploration a little less painful. Every five seconds the player becomes totally immune to damage for one second and will deal 40 contact damage to enemies. This item can be used, when timed properly, to get into Curse Rooms and open spiky chests without taking any damage.
This opens up a lot of doors for players, especially if there aren’t many Health Up items in a playthrough. It doesn’t have any particularly notable combos except for with the Gnawed Leaf, but the ability to do nothing while dealing small amounts of damage every five seconds isn’t worth going for. It’s one of the bestIsaacRepentanceitemsfor its long-term health-saving potential.
10Eye of the Occult
The Eye of the Occult item is very similar to the Ludovico Technique except that Isaac can fire more than one tear to control. Additionally, the Eye of the Occult increases Isaac’s damage by 1 and his range by 7.5, but it reduces his shot speed slightly.
The tears are controllable while in flight, which are otherwise like normal tears and are affected by Isaac’s range – but the item doeshave special interactionswith other items like Brimstone. It’s found only in the Devil Room, or with items that spawn Devil Room chests.
9Rock Bottom
WithRock BottomIsaac gains a passive item that simply prevents the player’s stats from being reduced by anything for the rest of the run. It pairs extremely well with Experimental Treatment by removing all downsides, as the item randomlyincreases and decreases stats.
However, while the item prevents outright stat reductions (e.g. from pills) it won’t stop multipliers from lowering the player’s damage. If an item multiplies the player’s damage by a percentage below 1, Rock Bottom doesn’t keep the original number. It can only be found in the Secret Room.
8Immaculate Heart
The Immaculate Heart gives Isaac a chance to shoot additional tears that orbit around him, defending him from close-by enemies. It also gives Isaac an extra red heart and adds an extra 20 percent damage to his shots.
The Immaculate Heartwould be a bit forgettableif not for the damage boost and extra health, and its extra ability to give Isaac orbiting tears bumps it above others significantly. As one of thebestRepentanceitems, it’sonly found in Angel Rooms.
7Member Card
The Member Card is an item that opens a special shop underneath the regular shop on each level. The item causes a trapdoor to spawn, which reveals the additional shop. It can contain up to 5 items, including trinkets, items, cards, runes, and various types of hearts.
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Each pedestal item in the room costs more than usual, anywhere from 15 to 30 cents for normal items and up to 99 cents for Secret Room items. The Member Card is unlocked by spending 40 coins in a single shop, making it one of the easiestThe Binding of Isaac Repentanceitemsto unlock.
6Genesis
Genesis is functionally a way to reset a run in the middle of the run. It teleports Isaac to a bedroom with two chests, two sacks, a trinket and a trap door that takes him to the next layer down (without having to clear the floor Isaac teleported from).
The item takes away every single item Isaac picked up in the runand offers a choiceof three items for each one taken away. At its worst, it’s an item that will change how you play the rest of the run. At it’s best, it flat-out breaks the game with the huge array of synergies presented.
5Mega Mush
The Mega Mush is a new mushroom-type item inThe Binding Of Isaac:Repentanceand, like the other mushrooms, significantlyaffects the player’s stats. When this active item is used, it makes Isaac turn gigantic for half a minute and increases his damage fourfold.
However, while the player is far more powerful and has a much longer range, the tear delay stat is also multiplied by 2.5 times. The slow shoot speed is balanced by the fact that Isaac turns invincible, deals contact damage, and can destroy just about anything in his path. To unlock this, the player must fully complete hard mode with all characters.
44.5 Volt
The 4.5 Volt is a passive item that changes the way the charge on active items works. Instead of gaining charge when completing rooms or picking up batteries, Isaac’s active item charges when he deals damage to enemies.
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His item will charge one bar’s worth for every 60 damage that Isaac deals to enemies. It should be unlocked from the get-go upon downloading the DLC, and it’s one of theIsaacRepentancebest itemsfor Greed Mode when paired with an active item.
3False PHD
The False PHD is very similar to the PHD item, but with a twist. They both identify pills before they are picked up, but whereas the PHD item gets rid of all negative pills in the game, the False PHD gets rid of everypositivepill.
Each pill that would normally cause a stat downalsogives Isaac asmall permanent damage boost. It gives one black pill when picked up, and can only be found in the Curse Room, the Devil Room, or in red chests.
